Will Ferrell, John C. Reilly, Michael Clarke Duncan, Sacha Baron Cohen, Gary Cole, Jane Lynch, Leslie Bibb, Houston Tumlin, Grayson Russell, Greg Germann, Amy Adams, David Koechner, Jack McBrayer, Ian Roberts, Ted Manson, Rob Riggle, Molly Shannon, Andy Richter, Jake Johnson, Jason Davis, Lorrie Bess Crumley, Luke Bigham, Austin Crim, Adam McKay, John D. King, Pat Hingle, Dale Earnhardt Jr., Dick Berggren, Mike Joy, Larry McReynolds, Darrell Waltrip, Jamie McMurray, Danny Vinson, Sylvia G. Lyerly, Dan Cox, Bob Jenkins, William Boyer, Ruffin Copeland, Rick Benjamin, Matt Day, Christoph Sanders, Pete Burris, Frank Hoyt Taylor, Conrad Ricamora, Angie Fox, Jim Bohampton, Rebecca Koon, Yasiin Bey, Elvis Costello, Bill Weber, Benny Parsons, Wally Dallenbach Jr., Jack Blessing, John Baker, Robert R. Lee, Matt Coulter, Ed Lauter, Paul Gibson, Peter Musooli, George Peroulas, Kevin Ledford, Mark A. Keeton, Cal Johnson, Robert P. Johnson II, Ernest 'Scooby' Rogers, JoAnn Bernat, Riley McDonald, Sam Fisicaro, Rose Davidson, Todd Davis, Cricket Ellis, Chad C. Hundley, Cody Lowe, Josh Church
Ricky Bobby e il suo amico Cal Naughton Jr. sono i dominatori assoluti delle classifiche del circuito NASCAR, ma ad insidiare il loro posto in vetta all'Olimpo dei piloti più forti e spericolati sta per arrivare il vivace pilota francese di Formula Uno Jean Girard...